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czcO [2019-01-02 16:02:16]
similar to flavin-containing monooxygenase, facilitates cation export via [protein|7FB5BCC16D688465A820F436F657C49625257884|CzcD]
function
resistance to toxic metal ions
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.4|Trace metals/ Other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.11|Resistance against toxic metals]Gene
Coordinates
2,722,767 → 2,723,804
The protein
Structure
[PDB|4USQ] (from Cellvibrio sp., 23% identity)Expression and Regulation
Operons
genes
[gene|7FB5BCC16D688465A820F436F657C49625257884|czcD]-[gene|6D6C324675631B5CAB165D6DF72AA45BF3DB6F29|czcO]
description
[Pubmed|15948947]
regulatory mechanism
[protein|6FB1865734C4DE7BE19D3D1A7E0C687B6D7094E1|CzrA]: repression, [Pubmed|15948947], in [regulon|6FB1865734C4DE7BE19D3D1A7E0C687B6D7094E1|CzrA regulon]regulation
induced in the presence of toxic metal ions (Zn(II), Cd(II), Co(II), Ni(II) and Cu(II)) ([protein|search|CzrA]) [Pubmed|15948947]view in new tabBiological materials
Mutant
BKE26640 (Δ[gene|6D6C324675631B5CAB165D6DF72AA45BF3DB6F29|czcO]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE26640 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACATTATCACCCCGCCAAT, downstream forward: _UP4_TAAACGAAGCAGAGCAGTAABKK26640 (Δ[gene|6D6C324675631B5CAB165D6DF72AA45BF3DB6F29|czcO]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK26640 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACATTATCACCCCGCCAAT, downstream forward: _UP4_TAAACGAAGCAGAGCAGTAAReferences
